Paper Details

Paper Code :  19897683

Paper Title   :  Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance

Journal Title   :  The Journal of clinical endocrinology and metabolism


J Clin Endocrinol Metab. 2010 Jan;95(1):256-62. Epub 2009 Nov 6.


CONTEXT: Brown adipose tissue (BAT) found by positron emission/computed tomography (PET-CT) using flouro-deoxyglucose (FDG) is inducible by cold exposure in men. Factors leading to increased BAT are of great interest for its potential role in the treatment of diabetes and obesity.

OBJECTIVE: We tested whether thyroid hormone (TH) levels are related to the volume and activity of BAT in a patient with a mutation in the insulin receptor gene. DESIGN/SETTING/INTERVENTION: Our work was based on the case report of a patient in an observational study at the National Institutes of Health.

PATIENT: The patient discontinued insulin and oral antidiabetics after thyroidectomy and suppressive-dose levothyroxine therapy for thyroid cancer. PET-CT uptake in BAT was confirmed by histology and molecular analysis.

OUTCOMES: PET-CT studies were performed, and we measured hemoglobin A1c and resting energy expenditure before and after levothyroxine discontinuation for thyroid cancer testing. Molecular studies of BAT and white adipose samples are presented.

RESULT: Supraclavicular and periumbilical sc adipose tissue demonstrated molecular features of BAT including uncoupling protein-1, type 2 deiodinase, and PR domain containing 16 by quantitative PCR. Activity of type 2 deiodinase activity was increased. The discontinuation of levothyroxine resulted in decreased FDG uptake and diminished volume of BAT depots accompanied by worsening of diabetic control.

CONCLUSIONS: This case demonstrates the TH effect on BAT activity and volume in this patient and an association between BAT activity and glucose levels in this patient. Because the contribution of TH on skeletal muscle energy expenditure and fuel metabolism was not assessed, an association between BAT activity and glucose homeostasis can only be suggested.



Please Be Advised

:: Ordering full-text copy of this paper is available.


Available Formats

:: Electronic copy (PDF) format.


Turnaround Time

:: Regular (within 24 to 72 hours) no additional charge.

:: Rush (within 8 to 12 working hours) 10 L.E.


Delivery Options

:: By E-mail (according to the size).



:: Click on Request this Paper Link in the Gray bar on this page.

:: A message with the final cost will deliver to your E-mail / Mobile.


Payment Options

:: Instant Money Transfer from any Egyptian's Post Office.

:: Bank Transfer Order to our Accounts Egypt / Saudi Arabia.

:: Deposit option (Minimum 50 L.E.).

Sign Up

Selected Papers

Published On Egypt


"EgyDoctor.Net gives me access to the right information in a timely fashion and supporting me in both of my M.Sc. and PH.D. in an efficient and economical way.

A. Hosni Ph.D., MRCS